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DISCLAIMER

PORPHYRIA FACTS is a medical education website dedicated to helping you focus your research on the inherited metabolic diseases known as the "Porphyrias".

PORPHYRIA FACTS is for individuals seeking information on Porphyria. The specific focus is on education, and research in the porphyrias.

PORPHYRIA FACTS present medical citations from medical professionals and others qualified and knowledgeable in the porphyrias.


PORPHYRIA FACTS takes no responsibility for medical information that is discussed here. You are encouraged to always seek medical advice before trying any new protocols. Open communication with your physician is important in developing effective treatment protocols.

PORPHYRIA FACTS:

ABDOMINAL PAIN


Characterization of hepatic acute porphyrias


Hepatic porphyrias are characterized by episodic acute attacks that consist of
various neuro-psychiatric symptoms and signs, such as abdominal pain,
associated with increased excretion of porphyrins and porphyrin precursors.

SOURCE:
Journal of Photodermatololy, Photoimmunologyand Photomedicine
1998 Apr;
14(2):48-54
"Management of the acute porphyrias."
Kauppinen R, M.D.
Department of Medicine,
University Hospital
Helsinki, Finland.
+++++++++++++

Abdominal pain experienced by the majority of acute porphyria patients

Abdominal pain and ileus are frequent presenting symptoms in porphyria and
may occur several years before neurologic illness.


SOURCE:
Acute Peripheral Neuropathy Due to Coproporphyria
Drs. Barohn, Sanchez & Anderson
"MUSCLE & NERVE"
July 1994
+++++++++++++

Vomiting accompanies ab pain

Vomiting most often accompanies the abdominal pain

Attacks of abdominal pain and vomiting may occur in most acute attacks.

SOURCE:
Dr. Stanley L. Wiener
"Differential Diagnosis of Acute Pain"
McGraw-Hill 1993
+++++++++++++++


Abdominal pain a trademark

Abdominal pain is commonly associated with the attack.

SOURCE:


Acute Intermittent Porphyria
Anne LeMaistre, M.D.
1995 TMC
++++++++++++++


Abdominal exams unremarkable


Abdominal examination in AIP usually finds nothing remarkable.

Despite the intense pain, the findings on abdominal examination often are
nonspecific.


SOURCE:
Medicine Journal
February 22 2002
Volume 3, Number 2
"Acute intermittent porphyria"
Thomas G DeLoughery, MD
Department of Medicine
Division of Hematology and Medical Oncology
Oregon Health Sciences University
Portland, Oregon
+++++++++++++++


Duration of abdominal pain


The abdominal pain of AIP is severe and can last for several days.


Severe abdomen pain of short (<1 d) duration or chronic abdominal pain is
unusual.

SOURCE:
Medicine Journal
February 22 2002
Volume 3, Number 2
"Acute intermittent porphyria"
Thomas G DeLoughery, MD
Department of Medicine
Oregon Health Sciences University
Portland, Oregon
+++++++++++++++


Perittonism absent in abdominal pain


Severe abdominal pain without signs of perittonism is seen in almost all attacks
of acute porphyria.

SOURCE:
Acute Porphyrias: Pathogenesis of
Neurological Manifestations
Urs. A Meyers M.D. et. al.
Seminars in Liver Disease
Vol. 18, Number 1
January 1998
+++++++++++++++++


Why abdominal pain?


It is believed that an imbalance in the autonomic innervation of the gut leads to
abdominal pain which is commonly associated with the attack.

The reasons are still unclear as to why the pain is present, however it is present
in almost 90 percent of all porphyric attacks.

SOURCE:
Lifelines:
Journal of Emergency Medicine
October 1998
123: 437-443
Emergency Treatment of the Porphyric Patient
Kirsch, N,.E., M.D.
+++++++++++++++++

Abdominal pain in remission


Acute attacks of porphyria may resolve quite radpidly.The abdominal pain can
disappear within a few hours.


SOURCE:
"The Porphyrias"
Karl E. Anderson M.D.
HEPATOLOGY:
A Textbook of Liver Disease
W.B. Saunders Company
Philadephia 1996
+++++++++++++++

Gastrointestinal dysfunction

Gastrointestinal dysfunction in the acute porphyrias frequently results in
disturbed gut motility.


SOURCE:
Acute Porphyrias: Pathogenesis of
Neurological Manifestations
Urs. A Meyers M.D. et. al.
Seminars in Liver Disease
Vol. 18, Number 1 p. 45
January 1998
+++++++++++++++++

While not everyone experiences abdominal pain, and while it may not be present
with every acute attack, abdominal pain still remains one of the major symptoms
of acute intermittent porphyria.

SOURCE:
Dr. Robert Johnson
Retired Clinician
PES Newsletter
August 2002
++++++++++++++++
During onsets of acute attacks the pain is mostly experienced in the upper right
quadrant of the abdomen.

SOURCE:
D. Montgomery Bissell MD
+++++++++++++++++++++

In 1959 Goldberg found in his study of porphyria patients that 94 % of the
porphyria patients indicated abdominal pain.

Twenty years later, in 1979 Drs. Stein and Tschudy found that 95% of all
porphyria patients indicate having the abominal pain.

SOURCE:
Dr. Robert Johnson
Retired Clinician
PES Newsletter
August 2002
+++++++++++++++++

The initial and commonest manifestation of HCP is abdominal pain, which
canbe diffuse or localized, colicky.

SOURCE:

The Porphyrias
Anderson, Karl E
Cecil Textbook of Medicine,
13th ed. Mc Graw Hill,
1994.
+++++++++++++++ +++++





















































EPORPHYRIA FACTS: PAIN - ABDOMINAL PAIN sent


Characterization of hepatic acute porphyrias


Hepatic porphyrias are characterized by episodic acute attacks that consist of
various neuro-psychiatric symptoms and signs, such as abdominal pain,
associated with increased excretion of porphyrins and porphyrin precursors.

SOURCE:
Journal of Photodermatololy, Photoimmunologyand Photomedicine
1998 Apr;
14(2):48-54
"Management of the acute porphyrias."
Kauppinen R, M.D.
Department of Medicine,
University Hospital
Helsinki, Finland.
+++++++++++++

Abdominal pain experienced by the majority of acute porphyria patients

Abdominal pain and ileus are frequent presenting symptoms in porphyria and
may occur several years before neurologic illness.


SOURCE:
Acute Peripheral Neuropathy Due to Coproporphyria
Drs. Barohn, Sanchez & Anderson
"MUSCLE & NERVE"
July 1994
+++++++++++++

Vomiting accompanies ab pain

Vomiting most often accompanies the abdominal pain

Attacks of abdominal pain and vomiting may occur in most acute attacks.

SOURCE:
Dr. Stanley L. Wiener
"Differential Diagnosis of Acute Pain"
McGraw-Hill 1993
+++++++++++++++


Abdominal pain a trademark

Abdominal pain is commonly associated with the attack.

SOURCE:


Acute Intermittent Porphyria
Anne LeMaistre, M.D.
1995 TMC
++++++++++++++


Abdominal exams unremarkable


Abdominal examination in AIP usually finds nothing remarkable.

Despite the intense pain, the findings on abdominal examination often are
nonspecific.


SOURCE:
Medicine Journal
February 22 2002
Volume 3, Number 2
"Acute intermittent porphyria"
Thomas G DeLoughery, MD
Department of Medicine
Division of Hematology and Medical Oncology
Oregon Health Sciences University
Portland, Oregon
+++++++++++++++


Duration of abdominal pain


The abdominal pain of AIP is severe and can last for several days.


Severe abdomen pain of short (<1 d) duration or chronic abdominal pain is
unusual.

SOURCE:
Medicine Journal
February 22 2002
Volume 3, Number 2
"Acute intermittent porphyria"
Thomas G DeLoughery, MD
Department of Medicine
Oregon Health Sciences University
Portland, Oregon
+++++++++++++++


Perittonism absent in abdominal pain


Severe abdominal pain without signs of perittonism is seen in almost all attacks
of acute porphyria.

SOURCE:
Acute Porphyrias: Pathogenesis of
Neurological Manifestations
Urs. A Meyers M.D. et. al.
Seminars in Liver Disease
Vol. 18, Number 1
January 1998
+++++++++++++++++


Why abdominal pain?


It is believed that an imbalance in the autonomic innervation of the gut leads to
abdominal pain which is commonly associated with the attack.

The reasons are still unclear as to why the pain is present, however it is present
in almost 90 percent of all porphyric attacks.

SOURCE:
Lifelines:
Journal of Emergency Medicine
October 1998
123: 437-443
Emergency Treatment of the Porphyric Patient
Kirsch, N,.E., M.D.
+++++++++++++++++

Abdominal pain in remission


Acute attacks of porphyria may resolve quite radpidly.The abdominal pain can
disappear within a few hours.


SOURCE:
"The Porphyrias"
Karl E. Anderson M.D.
HEPATOLOGY:
A Textbook of Liver Disease
W.B. Saunders Company
Philadephia 1996
+++++++++++++++

Gastrointestinal dysfunction

Gastrointestinal dysfunction in the acute porphyrias frequently results in
disturbed gut motility.


SOURCE:
Acute Porphyrias: Pathogenesis of
Neurological Manifestations
Urs. A Meyers M.D. et. al.
Seminars in Liver Disease
Vol. 18, Number 1 p. 45
January 1998
+++++++++++++++++

While not everyone experiences abdominal pain, and while it may not be present
with every acute attack, abdominal pain still remains one of the major symptoms
of acute intermittent porphyria.

SOURCE:
Dr. Robert Johnson
Retired Clinician
PES Newsletter
August 2002
++++++++++++++++
During onsets of acute attacks the pain is mostly experienced in the upper right
quadrant of the abdomen.

SOURCE:
D. Montgomery Bissell MD
+++++++++++++++++++++

In 1959 Goldberg found in his study of porphyria patients that 94 % of the
porphyria patients indicated abdominal pain.

Twenty years later, in 1979 Drs. Stein and Tschudy found that 95% of all
porphyria patients indicate having the abominal pain.

SOURCE:
Dr. Robert Johnson
Retired Clinician
PES Newsletter
August 2002
+++++++++++++++++

The initial and commonest manifestation of HCP is abdominal pain, which
canbe diffuse or localized, colicky.

SOURCE:

The Porphyrias
Anderson, Karl E
Cecil Textbook of Medicine,
13th ed. Mc Graw Hill,
1994.
+++++++++++++++ +++++





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