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AIP - ABDOMINAL PAIN
Abdominal pain trademark of AIP
Abdominal pain is commonly associated with the attack.
SOURCE:
Acute Intermittent Porphyria
Anne LeMaistre, M.D.
1995 TMC
++++++++++++
Almost always there is severe abdominal pain of short duration in AIP.
SOURCE:
Medicine Journal
February 22 2002
Volume 3, Number 2
+++++++++++++++
Often AIP may mimic an accute inflammatory abdominal disease with severe
pain.
SOURCE:
Metabolic Disorders
Porphyrias: Clinical Manifestations, Diagnosis and Treatment
Bernardo Haddock Lobo Goulart & Samanta Teixeira Basto
University Medical School, Brazil
+++++++++++
The initial and commonest manifestation of AIP is abdominal pain, which canbe
diffuse or localized, colicky.
SOURCE:
The Porphyrias
Anderson, Karl E
Cecil Textbook of Medicine,
13th ed. Mc Graw Hill,
1994.
++++++++++++
The clinical picture of AIP may mimic an accute inflammatory abdominal
disease.
SOURCE:
The Porphyrias
Anderson, Karl E
Cecil Textbook of Medicine,
13th ed. Mc Graw Hill,
1994.
+++++++++++++
The initial and commonest manifestation of AIP is abdominal pain, which can
be diffuse or localized, colicky.
SOURCE:
The Porphyrias
Anderson, Karl E
Cecil Textbook of Medicine,
13th ed. Mc Graw Hill,
1994.
++++++++++++
AIP symptoms consist of autonomic neuropathies (eg, constipation,
colicky abdominal pain, vomiting, hypertension), peripheral neuropathy,
seizures, delirium, coma, and depression.
SOURCE:
Medicine Journal
February 22 2002
Volume 3, Number 2
++++++++++++
There can be neurological changes in AIP.
SOURCE:
Acute Intermittent Porphyria
Guide to Disease
Columbia Health Systems
1996
+++++++++++
Peripheral neuropathy can present in AIP.
SOURCE:
Acute Intermittent Porphyria
Guide to Disease
Columbia Health Systems
1996
+++++++++++
In AIP mild sensory changes often accompany the predominantly motor
neuropathy--often in a "bathing trunk" distribution.
SOURCE:
British Medical Journal
Helen Thadani
Diagnosis and management of porphyria
Bristish Medical Journal
June 17, 2000
+++++++++++
AIP is characterized by potentially lethal acute attacks with abdominal pain.
SOURCE:
Molecular genetics of acute intermittent porphyria in Finland
Sami Mustajoki
Division of Endocrinology,
Department of Medicine,
University of Helsinki &
Department of Human Molecular Genetics,
National Public Health Institute, Finland
++++++++++++
The episodes of abdominal pain experienced during acute attacks may be so
severe as to indicate a need for immediate surgical exploration and intervention.
SOURCE:
Porphyria Resources
United Medical Services
1996
++++++++++++++
The most prominent fymptom of AIP is that of abdominal pain.
SOURCE:
Acute Intermittent Porphyria
Guide to Disease
Columbia Health Systems
1996
+++++++++++
Abdominal pain is the commonest manifestation of AIP.
SOURCE:
Metabolic Disorders
Porphyrias: Clinical Manifestations, Diagnosis and Treatment
Bernardo Haddock Lobo Goulart & Samanta Teixeira Basto
University Medical School, Brazil
+++++++++++++
Abdominal pain is the commonest manifestation of AIP.
SOURCE:
Metabolic Disorders
Porphyrias: Clinical Manifestations, Diagnosis and Treatment
Bernardo Haddock Lobo Goulart & Samanta Teixeira Basto
University Medical School, Brazil
+++++++++++++++
The abdominal pain of AIP is severe and lasts for several days.
Severe abdomen pain of short (<1 d) duration or chronic abdominal pain is
unusual."
SOURCE:
"Acute intermittent porphyria"
Thomas G DeLoughery, MD
Associate Director
Department of TransfusionMedicine
Division of Clinical Pathology
Associate Professor
Department of Medicine
Division of Hematology and Medical Oncology
Oregon Health Sciences University
Portland, Oregon
++++++++++++++
Abdominal pain experienced by the majority of AIP patients
Abdominal pain and ileus are frequent presenting symptoms in porphyria and
may occur several years before neurologic illness.
SOURCE:
Acute Peripheral Neuropathy Due toporphyria
Drs. Barohn, Sanchez & Anderson
"MUSCLE & NERVE"
July 1994
++++++++++
Abdominal exams in AIP are unremarkable
SOURCE:
Medicine Journal
February 22 2002
Volume 3, Number 2
++++++++++++
Abdominal examination in AIP usually finds nothing remarkable..
Despite the intense pain, the findings on abdominal examination often are
nonspecific.
SOURCE:
"Acute intermittent porphyria"
Thomas G DeLoughery, MD
Department of Medicine
Division of Hematology and Medical Oncology
Oregon Health Sciences University
Portland, Oregon
++++++++++++
t is believed that an imbalance in the autonomic innervation of the gut leads to
abdominal pain which is commonly associated with the attack.
The reasons are still unclear as to why the pain is present, however it is present
in almost 90 percent of all porphyric attacks.
SOURCE:
Lifelines:
Journal of Emergency Medicine
October 1998
123: 437-443
Emergency Treatment of the Porphyric Patient
Kirsch, N,.E., M.D.
++++++++++++
Abdominal pain disappears when in remission
Acute attacks of porphyria may resolve quite radpidly.The abdominal pain can
disappear within a few hours.
SOURCE:
"The Porphyrias"
Karl E. Anderson M.D.
HEPATOLOGY:
A Textbook of Liver Disease
W.B. Saunders Company
Philadephia 1996
++++++++++++
AIP abdominal pain can be colicky, diffuse or localized.
SOURCE:
The Porphyrias
Meyer, Urs A.
Harrison’s Principles of Internal Medicine,
12th ed. Mc GrawHill, 1991.
+++++++++++++
Duration of abdominal pain can last for several days.
Severe abdomen pain of short (<1 d) duration or chronic abdominal pain is
unusual.
SOURCE:
Medicine Journal
February 22 2002
Volume 3, Number 2
++++++++++++
Abdominal pain in AIP may be localized.
SOURCE:
Robert Johnson MD
Internal Medicine
+++++++++++++
Pains may last for hours or days.
SOURCE:
Dr. Robert Johnson M.D.
Retired Clinician
++++++++++
Abdominal pain is experienced by 91% of patients with Acute Intermittent
Porphyria (AIP).
SOURCE:
Porphyria
New Vision Medical Services
1997
+++++++++
AIP acute attacks present with with abdominal pain
SOURCE:
Jean-Charles Deybach, M.D., Ph.D.
Hôpital L. Mourier and Faculté de Médecine X. Bichat
Université Paris 7, France
+++++++++++
During acute attacks, whether abdominal pain is mild or severe, in most cases of
AIP, the recurring abdominal discomfort has caused patients to seek
examination.
SOURCE:
Porphyria Resources
United Medical Services
1996
++++++++++
The initial and commonest manifestation of AIP is abdominal pain, which
can be diffuse or localized, colicky.
SOURCE:
The Porphyrias
Anderson, Karl E
Cecil Textbook of Medicine,
13th ed. Mc Graw Hill,
1994.
++++++++++
The episodes of abdominal pain experienced during acute attacks may be so
severe as to indicate a need for immediate surgical exploration and
intervention.
SOURCE:
Porphyria Resources
United Medical Services
1996
+++++++++++
The abdominal pain of AIP is severe and can last for several days.
SOURCE:
"Acute intermittent porphyria"
Thomas G DeLoughery, MD
Department of Medicine
Oregon Health Sciences University
Portland, Oregon
++++++++++ ++++
The clinical picture of AIP may mimic an accute inflammatory abdominal
disease.
SOURCE:
The Porphyrias
Anderson, Karl E
Cecil Textbook of Medicine,
13th ed. Mc Graw Hill,
1994.
+++++++++++
Often the onset of an acute attack is mistaken for acute appendicitis.
SOURCE:
Robert Johnson MD
Internal Medicine
+++++++++++
Abdominal pain in AIP is localized to the epigastrium which is the upper and
middle region of the abdomen, located within the sternal angle.
It is possible for the abdominal pain to be generalized.
SOURCE:
Dr. Robert Johnson M.D.
Internal Medicine
++++++++++++++
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