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Depression & Porphyria
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PSYCHIATRIC - DEPRESSION


Despression is the lowering or decrease of functional activity.

Such depression can present during the mental changes that take place in
porphyria acute attacks.

SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric
++++++++++++++++


Depression is a mental state of depressed mood characterised by feelings of
sadness, despair and discouragement.

SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric
++++++++++++++++

Depression ranges from normal feelings of the blues through dysthymia to major
depression.

SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric
++++++++++++++++

Depression is often a part of the mental change that takes place with porphyria.

SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric
++++++++++++++++


Depression in many ways resembles the grief and mourning that follow
bereavement, there are often feelings of low self esteem, guilt and self reproach,
withdrawal from interpersonal contact and somatic symptoms such as eating and
sleep disturbances.

SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric
++++++++++++++++

Porphyria patients can sometimes experience depression along with acute
attacks.

SOURCE:
Robert Johnson MD
Internal Medicine
+++++++++++++++

Depression can be associated with acute attacks.

SOURCE:
Meditext Informational Systems
Disease Index
Porphyria
1999
+++++++++++++++

In severe cases of psychosis associated with mental change in acute attacks of
porphyria there can be depression and sometimes suicidal thoughts.

SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric
++++++++++++++++


There is a high prevalence of suicide among porphyria patients.

Often the porphyria patients who commits suicide has experienced depression.

SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric
++++++++++++++++

Often during periods of psychosis in acute porphyria, emotion is exhibited in an
abnormal manner.

Depression can be a part of the mental changes displayed.

SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric
++++++++++++++++


During periods of psychosis in oporphyria the patient can display disorganized
thought and/or speech.

SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric
+++++++++++++

There can be emotional and psychiatric problems such as depression.

SOURCE:
The Canadian Porphyria Foundation Inc.
Neepawa, Manitoba, Canada
++++++++++++++

Often during periods of psychosis in acute porphyria, emotion is exhibited in an
abnormal manner.


During periods of psychosis in porphyria the patient can display disorganized
thought and/or speech.

SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric
+++++++++++++

Porphyria patients often become psychotic and depression may accompany
such mental change.

SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric
+++++++++++++



Delusions or hallucinations that cause disorganized thinking can form during
times when patients are experiencing depression.
SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric
+++++++++++++

During mental change in porphyria patients can experience “the blues” which is
seen in depression.

SOURCE:
Robert Johnson MD
Internal Medicine
+++++++++++++++


During times of depression porphyria patients may present with unusual
behaviors and loss of touch with reality.

SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric
+++++++++++++


Depression can present as restlessness, insomnia, "blues" endless times of
crying, and inability to remember simple and routine things in daily life.

SOURCE:
British Journal Anaesthesiology
1998 Feb;
80(2):260-2
++++++++++++++

Depression in porphyria can be the inability to remember things, insomnia and
general restlessness.

SOURCE:
"Propofol and electroconvulsive therapy in a patient at risk from acute
intermittent porphyria."
McKeith IG, MD et.al.
Department of Anaesthesia and Intensive Care,
Newcastle General Hospital,
Newcastle upon Tyne UK
+++++++++++++++

Seasonal affect disorder, more commonly known as SAD, is not medically
associated with acute porphyria.

SOURCE:
Robert Johnson MD
+++++++++++++

Seasonal affective disorder is a type of depression brought on by the
gloom of winter. Learn how to shine a light on your darkness.

SAD can sometimes accompany acute porphyria episodes but it is not medically
related.

SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric
+++++++++++

Nutritional cuases of depression include deficiences in some B-complex
vitamins, calcium, magnesium, potassium, copper, iron, zinc, and essential fatty
acids.

SOURCE:
Vitamins and Minerals:
Healthy Diet & Safe Supplementation
Denise Mortimore
Element
2001
+++++++++++++++

Deficiency in some vitamins can contribute to the presentation of depression.

SOURCE:
Sheryl Wilson MNS, RD
+++++++++++++++

The excessive use of stimulants including tea, coffee, colas, excess sodium,
overindulgence in alcohol, toxic overload and a generally poor intake of nutrients
usually due to a lack of interest in food, can all contribute to depression.

SOURCE:
Vitamins and Minerals:
Healthy Diet & Safe Supplementation
Denise Mortimore
Element
2001
+++++++++++++++

In severe cases of psychosis associated with mental change in acute attacks of
porphyria there can be depression and sometimes suicidal thoughts.


Depression can be especially severe during acute attacks.

SOURCE:
"The Porphyrias"
Karl E. Anderson M.D.
HEPATOLOGY:
A Textbook of Liver Disease
W.B. Saunders Company
Philadephia 1996
++++++++++++++

There is a high prevalence of suicide among porphyria patients.

SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric
+++++++++++++

Often during periods of psychosis in acute porphyria, emotion is exhibited in an
abnormal manner. This can include depression.

SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric
+++++++++++++


During periods of psychosis in porphyria the patient can display disorganized
thought and/or speech.

SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric
+++++++++++++

Depression can be especially severe during acute attacks.

SOURCE:
"The Porphyrias"
Karl E. Anderson M.D.
HEPATOLOGY:
A Textbook of Liver Disease
W.B. Saunders Company
Philadephia 1996
++++++++++++

Research shows anxiety often coexists with depression.

SOURCE:
The Anxiety Disorders Education Program
National Institute of Mental Health
6001 Executive Blvd.
Room 8184, MSC 9663
Bethesda, MD 20892-9663
++++++++++

There can be emotional and psychiatric problems such as depression
associated with the acute porphyrias.

SOURCE:
The Canadian Porphyria Foundation Inc.
Neepawa, Manitoba, Canada
+++++++++++

Often porphyria patients due to their porphyria and due to their often times
chronic pain, xperienced renewed hope followed by periods of depression.

SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric Medicine
++++++++

Porphyria patients find themselves often experiencing unwarranted guilt and
then withdrawal.

You feel guilty over the things you've said and done. Instead of communicating
this guilt, you withdraw from people so that you won't take your anger out on
them.

You also feel guilty because you aren't able to do your full share anymore.

Instead of venting your frustrations, you may start to withhold your emotions and
keep them bottled up inside.

Most often this is associated with bouts of depression.


SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric Medicine
++++++++++

Some complications of peripheral neuropathy include depression.

SOURCE:
Mayo Health News
The Mayo Clinic
Rochester, MInnesota
+++++++++++++

In the acute porphyrias there can be depression.

Depression is a mood state that may be mild and short-lived or more severe and
persistent.

The latter, a mood disorder, is characterized by extreme sadness, hopelessness,
lack of self-worth and discouragement.

Signs and symptoms of depression include disruption of sleeping and eating
patterns and lack of energy.

Depression may also be called clinical depression, major depression and major
depressive disorder.

SOURCE:
Dr. Kenneth Carlson
Neuropsychiatric Medicine
++++++++++

Research shows anxiety
often coexists with depression.


SOURCE:

The Anxiety Disorders Education Program
National Institute of Mental Health
6001 Executive Blvd.
Room 8184, MSC 9663
Bethesda, MD 20892-9663
++++++++++++++

In a study oif porphyria patients in Poland it was found that during acute attacks
that the majority of porphyria patients demonstrate a depressive syndrome
state.

SOURCE:
Journal of Dermatology
1981 Jul-Aug;
68(4):503-4
"Depressive syndrome in porphyria".
Sobczyk P MD et. al
+++++++++++++++

Depression can result in the acute porphyrias.


SOURCE:
Psychiatric symptoms of inherited metabolic disease.
Estrov Y, Scaglia F, Bodamer OA.
Department of Psychiatry
University of California, San Diego
Journal of Inherited Metabolic Disease
2000 Feb;23(1):2-6
+++++++++++++ `

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