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PORPHYRIA FACTS: NUTRITION - GRAPEFRUIT
When and how was it discovered that grapefruit interefered with various
medications and could cause bad reactions?
Researchers first discovered an interaction between grapefruit juice and the
drugs felodipine (Plendil) and nifedipine (Adalat, Procardia), which are used to
treat cardiovascular disease.
Later studies showed that grapefruitjuice alters the blood levels of many other
drugs as well.
SOURCE:
Mayo Medical Education
Mayo Foundation
Rochester, MN
+++++++++++++++++++++++++
When taking medications be sure to avoid the use of grapefruit juice within an
hour either side of medication.
Grapefruit is a known inducer of the cytochrome P-450.
SOURCE:
Robert Johnson M.D.
Internal Medicine
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Grapefruit juice is unique among juices from citrus fruits.
Chemicals in grapefruit interfere with certain enzymes that break down
certaindrugs in your intestinal tract and liver.
SOURCE:
Arlene Morrison R.D
++++++++++++++++++++++++
What are the chemicals in grapefruit juice which make it unsafe to drink within
24 hours of taking medications?
Harmful chemicals are present in the pulp and peel of grapefruit as well as in the
juice.
For this reason, any grapefruit product - including dietary supplements that
contain grapefruit
bioflavonoids - can interact with medications.
You may also want to avoid tangelos, a hybrid grapefruit as they may have a
similar effect.
SOURCE:
Mayo Medical Education
Mayo Foundation
Rochester, MN
++++++++++++++++++++++++++
Grapefruit can result in higher-than-desired blood levels of the drug and an
increased risk of serious side effects.
The exact chemical or chemicals in grapefruit juice that cause this interaction
aren't known.
SOURCE:
Robert Johnson M.D.
Internal Medicine
+++++++++++++++++++++
What drugs are known to have bad side effects if taken duringthe same time
period as grapefruit is consumed?
Drugs that are known to have potentially serious interactions with grapefruit
products include:
a.. Antiseizure drugs such as carbamazepine
b.. (Carbatrol, Tegretol)
a.. Antidepressants such as buspirone
b.. (BuSpar), clomipramine (Anafranil)
c.. and sertraline (Zoloft)
a.. Benzodiazepines such as diazepam
b.. (Valium) and triazolam (Halcion)
a.. Calcium channel blockers such as
b.. felodipine (Plendil), nifedipine (Adalat,
c.. Procardia, nimodipine (Nimotop),
d.. nisoldipine (Sular) and possibly
e.. verapamil (Isoptin, Verelan)
a.. Human immunodeficiency virus (HIV)
b.. protease inhibitors such as saquinavir
c.. (Fortovase, Invirase) and indinavir (Crixivan)
a.. HMG-CoA reductase inhibitors such
b.. as simvastatin (Zocor), lovastatin
c.. (Mevacor) and atorvastatin (Lipitor)
a.. Immunosuppressant drugs such as
b.. cyclosporine (Neoral, Sandimmune), tacrolimus (Prograf) and sirolimus
(Rapamune)
a.. Antiarrhythmic drugs such as amiodarone (Cordarone)
Even waiting to take these medications up to
24 hours after you drink grapefruit juice doesn't prevent an interaction.
The best advice is to avoid grapefruit products if you take any of these drugs,
unless your doctor or pharmacist approves.
SOURCE:
Mayo Medical Education
Mayo Foundation
Rochester, MN
++++++++++++++++++++++++++++
There is strong evidence that the chemical elements of grapefruit consumption
alters effectiveness of many prescription and OTC drugs.
Grapefruit is a known inducer of the cyctochrome P-450.
SOURCE:
Sheryl Wilson MNS RD
++++++++++++++++++++++++++++
Grapefruit can alter the metabolism and absorption of many different
medications and therefore should be avoided.
SOURCE:
Rovert Johnson M.D.
Internal Medicine
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