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Cirrhosis Associated with Hepatic Porphyria
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PORPHYRIA FACTS:
CIRRHOSIS ASSOCIATED WITH HEPATIC PORPHYRIA

Cirrhosis of the liver is commonly associated with certain forms of porphyria.

SOURCE:
Robert Johnson MD
Internal Medicine
+++++++++++++

Cirrhosis is the destruction of normal liver tissue that leaves nonfunctioning scar
tissue surrounding areas of functioning liver tissue.

SOURCE:
Renae Baldwin FNP
Gastroenterology
++++++++++++

The liver performs dozens of key tasks — processing nutrients into forms your
body can use, manufacturing bile to help digest fats, getting rid of the larger
waste molecules (metabolites) that can't be filtered by your kidneys, and
regulating the amounts of sugar, protein and fat that enter your bloodstream.

A liver damaged by cirrhosis has fewer healthy cells to carry out these activities.

SOURCE:
Cirrhosis
The American Gastroenterological Association
Digestive Health & Nutrition
++++++++++++

Cirrhosis is a condition in which progressive and irreversible damage occurs to
your liver.

SOURCE:
Cirrhosis
The American Gastroenterological Association
Digestive Health & Nutrition
++++++++++++



Most of the common causes of liver injury result in cirrhosis and porphyria is one
that most often causes liver injury.

SOURCE:
Renae Baldwin FNP
Gastroenterology
++++++++++++

The signs and symptoms of cirrhosis may include:

Lack of appetite

Weight loss

Nausea

Small, red, spiderlike

blood vessels under your skin or easy bruising

Weakness

Fatigue

Yellowing of your skin and eyes (jaundice)

dark urine

Bleeding in your esophagus or intestines

Loss of interest in sex

Fluid in your abdomen

Swelling of legs and feet due to fluid

Mental confusion (encephalopathy)

SOURCE:
Cirrhosis
The American Gastroenterological Association
Digestive Health & Nutrition
+++++++++++++


The most common cause of cirrhosis is alcohol abuse.

Alcohol is one of the leading causs of PCT as well.

SOURCE:
Renae Baldwin FNP
Gastroenterology
++++++++++++

The damage to liver cells causes scarring within the organ is called cirrhosis.

SOURCE:
Cirrhosis
The American Gastroenterological Association
Digestive Health & Nutrition
++++++++++++++



Chronic hepatitis is a major cause of cirrhosis and is often found in PCT
patients.

SOURCE:
Renae Baldwin FNP
Gastroenterology
++++++++++++

Poprhyria patients with mild cirrhosis have few symptoms and appear to be well
for years.

Some porphyria patients are weak, have a poor appetite, feel sick, and lose
weight.

If bile flow is chronically obstructed, the porphyria patients with cirrhosis have
jaundice, itching, and small yellow skin nodules, especially around the eyelids.

SOURCE:
Renae Baldwin FNP
Gastroenterology
++++++++++++

Besides alcohol abuse, cirrhosis can be caused by toxins, and disease.

SOURCE:
Cirrhosis
The American Gastroenterological Association
Digestive Health & Nutrition
++++++++++++

Cirrhosis of the liver can be due to certain forms of porphyria.

SOURCE:
Robert Johnson MD
Internal Medicine
++++++++++++


Malnutrition in porphyria patients with cirrhosis commonly results from a poor
appetite and the impaired absorption of fats and fat-soluble vitamins caused by
the reduced production of bile salts.

SOURCE:
Renae Baldwin FNP
Gastroenterology
++++++++++++

Patients with untreated PCT for a significant period of time may develop
cirrhosis.

SOURCE:
Medic Handbook
1995
++++++++++++




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